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Book Demo
  • Our Tech 
    • Gateway
    • Navigator
    • Copilot
    • AI Self-Help
  • For Healthcare 
    • Children and Young People
    • Outside the clinic
    • Collaborative Care (CoCM)
    • Physical Therapy
    • NHS Talking Therapies
  • For Insurers
  • For Impact
  • For Work 
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    • For Teams
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    • Reports
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    • Case Studies
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    • Our Tech 
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      • Navigator
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      • AI Self-Help
    • For Healthcare 
      • Children and Young People
      • Outside the clinic
      • Collaborative Care (CoCM)
      • Physical Therapy
      • NHS Talking Therapies
    • For Insurers
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  • Wysa has a strong base of clinical evidence in behavioral health, with peer-reviewed trials and efficacy studies across a range of clinical concerns, geographies and age groups.

    See our research
  • Wysa has a strong base of clinical evidence in behavioral health, with peer-reviewed trials and efficacy studies across a range of clinical concerns, geographies and age groups.

    See our research
  • Research Partners

  • Wysa Receives FDA Breakthrough Device Designation for AI-led Mental Health Conversational Agent

    The FDA Breakthrough Device Designation follows an independent peer-reviewed clinical trial, published in JMIR, that found Wysa to be effective in the management of chronic pain, and associated depression and anxiety. The device was found to be more effective than standard orthopedic care, and comparable to in-person psychological counseling.

    Read the article
  • Research at Wysa

    Our behavioural health evidence consists of independent clinical trials that have sought to examine the solution with scientific rigor, and through the lens of real-world implementation. The studies are strongly guided by the voice of the user through co-design and qualitative methodologies, and document our work across clinical concerns of depression, anxiety, pain and chronic conditions.

    8

    Clinical Trials

    6

    Service Evaluations

    13

    Real-World Studies

  • Peer-Reviewed Research

    Wysa has more than 36 peer-reviewed publications in partnership with academic institutions such as Cambridge University, Harvard University and Washington University of St. Louis amongst others, demonstrating the efficacy of Wysa across multiple clinical concerns. Contact us for the entire list of our publications.

    Effectiveness of a Mental Health Chatbot for People With Chronic Diseases: Randomized Controlled Trial

    Understanding Digital Mental Health Needs and Usage with an AI-led Mental Health App (Wysa) during the COVID-19 Pandemic: Retrospective Analysis

    A Digital Mental Health Intervention in an Orthopedic Setting for Patients With Symptoms of Depression and/or Anxiety: Feasibility Prospective Cohort Study

    Multi-stakeholder perspectives regarding preferred modalities for mental health intervention delivered in the orthopedic clinic: a qualitative analysis

    Perceptions of a Digital Mental Health Platform Among Participants With Depressive Disorder, Anxiety Disorder, and Other Clinically Diagnosed Mental Disorders in Singapore: Usability and Acceptability Study

    Language Adaptations of Mental Health Interventions: User Interaction Comparisons with an AI-enabled Conversational Agent (Wysa) in English and Spanish

    Understanding the impact of an AI-enabled Conversational Agent (Wysa) on users with a self-reported maternal event: A mixed method real-world data study

    Adherence and Engagement With a Cognitive Behavioral Therapy-Based Conversational Agent (Wysa for Chronic Pain) Among Adults With Chronic Pain: Survival Analysis

    Evaluating User Feedback for an Artificial Intelligence-Enabled, Cognitive Behavioral Therapy-Based Mental Health App (Wysa): Qualitative Thematic Analysis

    An Empathy-Driven, Conversational Artificial Intelligence Agent (Wysa) for Digital Mental Well-Being: Real-World Data Evaluation Mixed-Methods Study​

    Understanding People With Chronic Pain Who Use a Cognitive Behavioral Therapy–Based Artificial Intelligence Mental Health App (Wysa): Mixed Methods Retrospective Observational Study

    Evaluating the Therapeutic Alliance With a Free-Text CBT Conversational Agent (Wysa): A Mixed-Methods Study

    A Digital Mental Health Intervention in an Orthopedic Setting for Patients With Symptoms of Depression and/or Anxiety: Feasibility Prospective Cohort Study

  • Partner with Wysa for Research

    We aim to support the innovation and evidence-building within digital mental health and are always looking to connect with researchers.

    Contact us
  • One of our first studies was a real-world mixed methods study on the effectiveness and engagement of Wysa on anonymous global users.

    Watch Dr. Becky Inkster talk about the research study published in JMIR mHealth & uHealth.

    Read the study
  • Peer-reviewed research

    Our Clinical Development and Research team has completed over 15 peer-reviewed publications in partnership with academic institutions such as Cambridge University, Harvard University and Washington University of St. Louis amongst others demonstrating the efficacy of Wysa across multiple clinical concerns.

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    Adherence and Engagement With a Cognitive Behavioral Therapy-Based Conversational Agent (Wysa for Chronic Pain) Among Adults With Chronic Pain: Survival Analysis

    By: XXX, XXX, XXXX

    Read More
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    Evaluating User Feedback for an Artificial Intelligence-Enabled, Cognitive Behavioral Therapy-Based Mental Health App (Wysa): Qualitative Thematic Analysis

    By: XXX, XXX, XXXX

    Read More
    Section image

    An Empathy-Driven, Conversational Artificial Intelligence Agent (Wysa) for Digital Mental Well-Being: Real-World Data Evaluation Mixed-Methods Study​

     

    By: XXX, XXX, XXXX

    Read More
    Section image

    Understanding People With Chronic Pain Who Use a Cognitive Behavioral Therapy–Based Artificial Intelligence Mental Health App (Wysa): Mixed Methods Retrospective Observational Study

    By: XXX, XXX, XXXX

    Read More
    Section image

    Evaluating the Therapeutic Alliance With a Free-Text CBT Conversational Agent (Wysa): A Mixed-Methods Study

     

     

     

    By: XXX, XXX, XXXX

    Read More
    Section image

    A Digital Mental Health Intervention in an Orthopedic Setting for Patients With Symptoms of Depression and/or Anxiety: Feasibility Prospective Cohort Study

     

    By: XXX, XXX, XXXX

    Read More
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    Copyright 2026 at Wysa Ltd, All Rights Reserved.